1. School of
Computer Science & Engineering, The Hebrew University,
Jerusalem 91904, Israel
2. Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel
3. These authors contributed equally to this manuscript
Results: We present a general, accurate and efficient method for this task, applicable to any probabilistic binding site and background models. We demonstrate the accuracy of the method on synthetic and real-life data.
Availability: The algorithm used to compute the statistical significance of putative binding sites scores is available online at http://compbio.cs.huji.ac.il/CIS
Download ISMB/ECCB 2004 short
A short explanation about importance sampling and the CIS method.